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目的探讨前列地尔联合肾康注射液治疗老年慢性肾脏疾病患者的临床效果。方法所选研究对象为2015年12月至2016年12月大连市中心医院收治的老年慢性肾脏疾病患者,共86例。按照治疗方法不同,将86例老年慢性肾脏疾病患者分为两组,研究组患者给予前列地尔+肾康注射液治疗,对照组患者给予常规治疗。比较两组患者治疗效果、不良反应发生情况及治疗前后血肌酐、肌酐清除率、尿素氮、24 h尿蛋白、血清胱抑素C、血β2微球蛋白等实验室指标变化情况。结果研究组患者治疗的总有效率高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05);就诊时,两组患者血肌酐、肌酐清除率、尿素氮、24 h尿蛋白、血清胱抑素C、血β2微球蛋白水平比较,差异均无统计学意义(均P>0.05);治疗后,研究组患者血肌酐、肌酐清除率、尿素氮、24 h尿蛋白、血清胱抑素C、血β2微球蛋白水平均优于对照组,差异均有统计学意义(均P<0.05)。结论在老年慢性肾脏疾病患者治疗中,采用前列地尔与肾康注射液联合治疗效果理想。
Objective To investigate the clinical effects of alprostadil combined with Shenkang injection in the treatment of elderly patients with chronic kidney disease. Methods Selected subjects were aged chronic kidney disease patients admitted to Dalian Central Hospital from December 2015 to December 2016, a total of 86 cases. According to different treatment methods, 86 elderly patients with chronic kidney disease were divided into two groups. Patients in the study group were treated with alprostadil plus Shenkang injection, and patients in the control group were given routine treatment. The changes of laboratory indexes such as the treatment effect, adverse reactions and serum creatinine, creatinine clearance, urea nitrogen, 24 h urinary protein, serum cystatin C and blood β2 microglobulin before and after treatment were compared between the two groups. Results The total effective rate of treatment in study group was higher than that in control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05) Creatinine, creatinine clearance, urea nitrogen, 24 h urinary protein, serum cystatin C, blood β2 microglobulin levels, the difference was not statistically significant (all P> 0.05); after treatment, the study group patients serum creatinine, Creatinine clearance, urea nitrogen, 24 h urine protein, serum cystatin C, blood β2 microglobulin levels were better than the control group, the difference was statistically significant (P <0.05). Conclusion Alzheimer’s treatment with Shenkandian injection is effective in elderly patients with chronic kidney disease.