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目的:观察和对比单一药物或多药联合对功能性消化不良(FD)的治疗效果。方法:单一药物治疗有4种方法:改善胃动力治疗(A法),抗酸治疗(B法),抗幽门螺杆菌(Hp)治疗(C法),精神心理治疗(D法)。双药联合治疗共6种方法:改善胃动力与抗酸治疗(A+B法),改善胃动力与抗Hp治疗(A+C法),改善胃动力与精神心理治疗(A+D法),抗酸与抗Hp治疗(B+C法),抗酸与精神心理治疗(B+D法)和抗Hp与精神心理治疗(C+D法);三药联合治疗:改善胃动力、抗酸与抗Hp治疗(A+B+C法);综合治疗:改善胃动力、抗酸、抗Hp与精神心理治疗(A+B+C+D法)。结果:总有效率A法56.5%,B法52.4%,C法48.0%,D法38.1%;A+B法78.3%,A+C法69.6%,A+D法65.0%,B+C法68.2%,B+D法59.1%,C+D法52.6%;A+B+C法83.3%;A+B+C+D法95.0%。A,B,C法与D法比较,差异有统计学意义(P<0.05),A法与B法比较,差异无统计学意义(P>0.05),A法与C法比较,差异有统计学意义(P<0.05)。综合治疗(A+B+C+D法)总有效率(95.0%)>三药联合(83.3%)>双药联合(65.9%)>单药(48.9%),差异均有统计学意义(P<0.05)。结论:联合用药对功能性消化不良的治疗效果优于单一用药,而综合治疗则可达到最佳治疗效果。
Objective: To observe and compare the therapeutic effects of single drug or multi-drug combination on functional dyspepsia (FD). Methods: There are four kinds of single drug therapy: improving gastric motility treatment (A method), antacid therapy (B method), anti-Helicobacter pylori (C method), psychotherapy (D method). There are 6 ways to improve gastric motility and antacid therapy (A + B), improve gastric motility and anti-Hp therapy (A + C), improve gastric motility and psychotherapy (A + D) , Anti-acid and anti-Hp treatment (B + C method), acid and psychotherapy (B + D method) and anti-Hp and psychotherapy (C + D method); triple therapy: to improve gastric motility, anti Acid and anti-Hp treatment (A + B + C method); Comprehensive treatment: improve gastric motility, acid resistance, anti-Hp and psychotherapy (A + B + C + D method). Results: The total effective rate was 56.5% in A method, 52.4% in B method, 48.0% in C method and 38.1% in D method, 78.3% in A + B method, 69.6% in A + C method and 65.0% in A + D method 68.2%, 59.1% for the B + D method, 52.6% for the C + D method, 83.3% for the A + B + C method and 95.0% for the A + B + C + D method. There was no significant difference between A, B, C and D (P <0.05), but there was no significant difference between A and B (P> 0.05). There was statistical difference between A and C Significance (P <0.05). The total effective rate (95.0%) of combination therapy (A + B + C + D)> combination of three drugs (83.3%)> combination of two drugs (65.9%)> single drug (48.9%) were statistically significant P <0.05). Conclusion: The combined treatment of functional dyspepsia better than single treatment, and comprehensive treatment can achieve the best therapeutic effect.