论文部分内容阅读
早在本世纪初,人们就知道黄体提取物有抑制排卵的作用,到1934年开始第一次从黄体中分离到结晶——黄体酮(1)。并且证明它对动物和人类均具有抑制排卵和维持妊娠的功效。因此黄体激素又称保孕激素。但是孕酮几乎没有口服活性以致于无法扩大应用。1937年,合成了17α-乙炔睾丸素(2a),它是具有较高口服活性的孕激素。1944年,从强心甙(3)合成得到少量的19-失碳孕酮(4)的粗品,而它在动物却显示出和纯品(1)具有同样强度的孕素活性。这两者的发现引起了人们极大的兴趣,从
As early as the beginning of this century, people know that luteinizing extract has the effect of inhibiting ovulation, and for the first time in 1934, the crystal-progesterone (1) was isolated from the corpus luteum. And it proves that it has the effect of inhibiting ovulation and maintaining pregnancy in both animals and humans. Therefore, progesterone, also known as progesterone hormone. But progesterone has almost no oral activity so that it can not expand the application. In 1737, 17α-acetylene testosterone (2a) was synthesized, which is a progestin with higher oral activity. In 1944, a small amount of the crude 19-nor-progesterone (4) was synthesized from cardiac glycosides (3), whereas it showed the same intensity of progestin activity in animals as the pure product (1). The discovery of both has aroused great interest from people