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在慢性乙型肝炎病毒(HBV)感染过程中,患者一般经历过免疫耐受期[乙型肝炎e抗原(HBeAg)阳性、HBV DNA 水平高、丙氨酸氨基转移酶(ALT)正常、组织学炎症坏死轻或无]、免疫清除期(HBeAg阳性、HBV DNA水平高、ALT 升高、肝组织炎症坏死明显)后发生HBeAg血清转换而进入低复制期,即HBeAg转阴、抗-HBe出现、HBV DNA水平很低、ALT正常、肝组织炎症坏死较轻或无。但部分患者由于HBV 发生了前C区基因突变导致HBeAg不能产生,或基本核心启动子(BCP)基因突变导致HBeAg表达水平下降,这种患者血清
In the course of chronic hepatitis B virus (HBV) infection, patients generally experience immune tolerance [HBeAg positive, high HBV DNA levels, normal alanine aminotransferase (ALT), histology Inflammation and necrosis of light or no], immune clearance (HBeAg-positive, high level of HBV DNA, elevated ALT, liver inflammation and necrosis obvious) after HBeAg seroconversion into the low replication stage, that HBeAg negative, anti-HBe appear, HBV DNA levels are low, normal ALT, liver inflammation and necrosis less or no. However, in some patients, HBeAg can not be produced due to pre-C gene mutations in HBV or mutations in basic core promoter (BCP) lead to a decrease in HBeAg expression. Serum