目的 :鼻咽癌是我国南方地区高发的恶性肿瘤之一 ,长期以来 ,对鼻咽癌发病分子机制未能彻底阐明 ,关键问题之一是缺乏一个良好的体外多阶段细胞模型。虽然利用ＥＢ病毒已建立了数个灵长类上皮细胞系 ,但是 ,ＥＢ病毒转化的人鼻咽上皮永生化细胞系尚为空白。目前认为 ,上皮细胞 OBJECTIVE: Nasopharyngeal carcinoma is one of the most malignant tumors in southern China. For a long time, the molecular mechanism of nasopharyngeal carcinoma has not been completely elucidated. One of the key problems is the lack of a good multi-stage cell model in vitro. Although several primate epithelial cell lines have been established using Epstein-Barr virus, EBV-transformed human nasopharyngeal epithelial immortalized cell lines are still blank. Currently think that epithelial cells