论文部分内容阅读
目的观察制备的消糜栓质量稳定性,对家兔阴道粘膜刺激性及临床治疗宫颈糜烂的疗效。方法消糜栓三批,采用阴凉处室内保存6个月,考察其质量;粘膜刺激性,对家兔分消糜栓组、空白基质对照组和空白对照组。消糜栓组、空白基质对照组,阴道给药(或空白基质)1g/(次.d),连续给药1周。刺激性结果,实行积分制,进行刺激性强度评定;临床疗效设观察组50例(消糜栓),对照组(复方莪术油栓)30例。治疗1~3个疗程,每个疗程进行复查。结果消糜栓三批样品放置6个月后,经测定均符合标准要求;消糜栓和空白基质对家兔阴道刺激性平均分值为0.25;临床疗效,消糜栓对宫颈糜烂治愈率为72.9%,总有效率97.9%;复方莪术油栓治愈率为75.9%,总有效率为96.6%;两组比较P>0.05。结论消糜栓质量稳定,对家兔阴道粘膜无刺激性(0~0.4),且治疗宫颈糜烂疗效确切。
OBJECTIVE To observe the stability of the quality of Xiaozhi suppository, the irritation of vaginal mucous membrane in rabbits and the clinical efficacy of cervical erosion treatment. Methods Three batches of Xiaotan Shuan were stored in the cool place for 6 months, and the quality was investigated. Mucosal irritability was applied to the rabbits. The control group and blank control group were divided into four groups. Acupuncture group, blank matrix control group, vaginal administration (or blank matrix) 1g/(d.d), continuous administration for 1 week. Irritant results, the implementation of points system, stimulating intensity assessment; Clinical efficacy set observation group 50 cases (Xi Xiao Shuan), the control group (compounds Curcuma oil suppository) 30 cases. Treatment 1 to 3 courses, each course of review. Results After the three batches of Xiaoying Suppository were placed for 6 months, they all met the standard requirements. The average score of vaginal irritation of rabbits was 0.25. The clinical curative effect of Xiaoyu suppository against cervical erosion was 72.9%, the total effective rate of 97.9%; compound Curcuma oil plug cure rate was 75.9%, the total effective rate was 96.6%; two groups P> 0.05. Conclusion The Xiaoyu suppository is stable in quality and has no irritation to the vaginal mucosa of rabbits (0~0.4). The curative effect of cervical erosion is definite.