2型糖尿病(Type 2 diabetes mellitus,T2DM)是一组由遗传和环境因素共同作用而引起的代谢综合征[1]。据中华医学会糖尿病分会的统计目前中国T2DM的发病率达9.7%[2]。胰岛细胞功能缺陷和胰岛素抵抗(insulinresistanceIR)是T2DM发生的两个重要的病理生理学基础。为此“糖毒性”与“胰岛素抵抗”成为大家关注点。1糖毒性“糖毒性”在T2DM发展过程中起着非常重要的作用。当胰岛的β细胞不能分泌足量的胰岛素时,血糖升高。高血糖具有双向性作用,短期高血糖对胰岛素分泌和葡萄糖利用有刺激作用,而当长期慢性血糖持续升高,特 Type 2 diabetes mellitus (T2DM) is a group of metabolic syndrome caused by genetic and environmental factors [1]. According to statistics from the Diabetes Branch of the Chinese Medical Association, the incidence of T2DM in China is currently 9.7% [2]. Islet cell dysfunction and insulin resistance IR are two important pathophysiological bases for the development of T2DM. To this end “sugar toxicity ” and “insulin resistance ” become our focus. 1 sugar toxicity “sugar toxicity ” plays a very important role in the development of T2DM. When islet β cells can not secrete enough insulin, blood sugar increased. Hyperglycemia has a two-way effect, short-term hyperglycemia on insulin secretion and glucose utilization have a stimulating effect, and when long-term chronic blood glucose continued to rise, especially