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目的 测定严重急性呼吸综合征 (SARS)患者血清Ⅲ型前胶原、Ⅳ型胶原含量变化 ,探讨其作为反映早期纤维化肺指标的价值。方法 用放射免疫法检测 66例SARS患者血清Ⅲ型前胶原、Ⅳ型胶原含量 ,与正常对照组比较。结果 血清Ⅲ型前胶原含量两组间比较无显著性差异(P >0 0 5)。SARS组恢复期Ⅳ型胶原含量明显高于SARS组进展期及对照组 (P <0 0 1)。X线胸片病灶吸收缓慢者Ⅳ型胶原含量较高。结论 部分SARS患者体内血清Ⅳ型胶原含量增高 ,与肺部病灶吸收和纤维化程度有关。检测血清Ⅳ型胶原水平可能是早期监测肺纤维化的一个较好指标
Objective To determine the changes of serum type Ⅲ procollagen and type Ⅳ collagen in patients with severe acute respiratory syndrome (SARS) and to explore its value as a predictor of early fibrosis. Methods The levels of serum type Ⅲ procollagen and type Ⅳ collagen in 66 patients with SARS were detected by radioimmunoassay, compared with the normal control group. Results There was no significant difference in serum procollagen type Ⅲ between the two groups (P> 0.05). The recovery of type Ⅳ collagen in SARS group was significantly higher than that in SARS group and control group (P <0.01). X-ray lesions slowly absorbed type Ⅳ collagen content higher. Conclusion Some patients with SARS have higher level of serum type Ⅳ collagen, which is related to the extent of lung lesion absorption and fibrosis. Detecting serum type IV collagen levels may be a good indicator of early monitoring of pulmonary fibrosis