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目的:探讨三种不同方法检测梅毒抗体的应用结果。方法:采用梅毒酶联免疫吸附试验(TP-ELISA)、梅毒螺旋体抗体快速血浆反应素试验(RPR)和梅毒螺旋体胶凝试验(TPPA)三种不同方法检测阳性标本80例,比较分析其灵敏性与特异性。结果:三种不同方法检测梅毒抗体的灵敏性、特异性及阳性预期值依次为TPPA、TP-ELISA、RPR,且RPR和TPPA数据差异具有统计学意义(P<0.05)。结论:TP-ELISA是检测梅毒的理想方法,RPR适用于检测梅毒非特异性抗体,TPPA适用于筛查后的阳性标本梅毒抗体的确证试验。
Objective: To explore the application of three different methods to detect syphilis antibody. Methods: Eighty positive samples were detected by TP-ELISA, RPR and TPPA. The sensitivity and specificity were compared between the two methods And specificity. Results: The sensitivity, specificity and positive predictive value of three different methods for the detection of syphilis antibody were TPPA, TP-ELISA and RPR, respectively. The difference between RPR and TPPA was statistically significant (P <0.05). Conclusion: TP-ELISA is an ideal method for the detection of syphilis. RPR is suitable for the detection of nonspecific syphilis antibody. TPPA is suitable for confirmatory test of positive syphilis antibodies after screening.