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目的 :研究异丙酚联合应用不同剂量的芬太尼在人工流产手术的麻醉作用。方法 :ASAⅠ～Ⅱ级人工流产患者 6 4例 ,随机分为三组 ,A组 2 2例为对照组 ,B组 2 2例 ,C组 2 0例。A组静注异丙酚 2mg/kg ,B组静注异丙酚2mg/kg及 1μg/kg芬太尼 ,C组静注异丙酚 2mg/kg及 2 μg/kg芬太尼。异丙酚均于 45～ 6 0秒缓慢注入。观察三组患者诱导及苏醒时间、异丙酚用量及呼吸抑制情况。结果 :麻醉诱导时间B、C两组少于A组 (P <0 0 1) ,苏醒时间B组少于A组 (P <0 0 5 )。异丙酚用量B、C两组均少于A组 (P <0 0 1)。呼吸抑制发生率A组 45 %、B组 5 0 %、C组85 % ,A、B两组的发生率接近 ,无显著性差异 ,但两组均与C组相差显著 (P <0 0 1,P <0 0 5 )。而呼吸抑制的平均时间B组为最短。结论 :异丙酚联合应用芬太尼用于人工流产手术麻醉可加强镇痛 ,减少异丙酚用量。异丙酚联合应用1μg/kg芬太尼 ,是一种较为安全有效的配伍方法。
Objective: To study the anesthetic effects of propofol combined with different doses of fentanyl in induced abortion. Methods: Sixty-four ASA Ⅰ ~ Ⅱ induced abortion patients were randomly divided into three groups: 22 cases in control group, 22 cases in control group and 20 cases in control group. Group A received intravenous propofol 2 mg / kg, Group B received intravenous propofol 2 mg / kg and 1 μg / kg of fentanyl, Group C received intravenous propofol 2 mg / kg and 2 μg / kg of fentanyl respectively. Propofol are slowly injected 45 ~ 60 seconds. Three groups of patients were observed induction and wake time, propofol dosage and respiratory depression. Results: The time of anesthesia induction in group B and C was less than that in group A (P <0.01), and the recovery time in group B was less than that in group A (P <0.05). The dosage of propofol B and C in both groups were less than that in group A (P <0.01). The incidence of respiratory depression was 45% in group A, 50% in group B and 85% in group C, and there was no significant difference between group A and group B, but the difference between group C and group C was significant (P <0.01 , P <0 0 5). The mean time of respiratory depression in group B was the shortest. Conclusion: Propofol combined with fentanyl for artificial abortion anesthesia can enhance analgesia and reduce the dosage of propofol. Propofol combined with 1μg / kg fentanyl, is a more safe and effective method of compatibility.