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目的探讨六味五灵片联合阿德福韦酯治疗慢性乙型肝炎肝纤维化的临床效果。方法选取2010年3月—2012年3月浑源县某院收治的慢性乙型肝炎肝纤维化患者76例,随机分为试验组与对照组,各38例。对照组患者予以阿德福韦酯治疗,试验组患者在对照组基础上加用六味五灵片治疗。观察两组患者临床效果及治疗前后肝功能指标〔丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血清总胆红素(TBi L)〕变化情况。结果试验组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者ALT、AST、TBi L水平比较,差异无统计学意义(P>0.05);治疗后试验组患者ALT、AST、TBi L水平低于对照组,差异有统计学意义(P<0.05)。结论六味五灵片联合阿德福韦酯治疗慢性乙型肝炎肝纤维化的临床效果显著,可有效改善患者临床症状,促进患者康复。
Objective To investigate the clinical effect of Liuwei Wuling tablet combined with adefovir dipivoxil on chronic hepatitis B liver fibrosis. Methods From March 2010 to March 2012, 76 patients with chronic hepatitis B liver fibrosis admitted to a hospital in Hunyuan County were randomly divided into experimental group and control group, with 38 cases in each group. Patients in the control group were treated with adefovir dipivoxil, and patients in the test group were treated with Liuwei Wuling tablets on the basis of the control group. The clinical effects and changes of liver function indexes (ALT, AST, TBiL) before and after treatment were observed. Results The total effective rate of patients in trial group was higher than that in control group (P <0.05). There was no significant difference in ALT, AST and TBi L between the two groups before treatment (P> 0.05) The levels of ALT, AST and TBi L in the experimental group were lower than those in the control group (P <0.05). Conclusion Liuwei Wuling tablets combined with adefovir dipivoxil treatment of chronic hepatitis B liver fibrosis clinical effect is significant, which can effectively improve the clinical symptoms and promote patient rehabilitation.