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目的 :研究E cadherin在甲状腺乳头状腺癌中的表达 ,并探讨其能否成为甲状腺乳头状腺癌独立的预后因素。方法 :应用免疫组化方法 ,对 40例甲状腺乳头状腺癌、10例甲状腺滤泡型腺瘤和 10例甲状腺正常组织进行了E cadherin表达的研究 ,并对可能影响甲状腺癌病人预后的有关因素进行了时序检验单因素生存分析。结果 :9例 (2 2 5 % )甲状腺乳头状腺癌E cadherin表达阳性 ,余多数呈不表达或弱阳性表达 ,2 0例良性对照均为阳性表达 ,差异有显著性 (P <0 0 5 ) ,17例有淋巴结转移的肿瘤其阳性表达率 (5 9% )明显低于无淋巴结转移的阳性表达率(34 78% ) ,(P <0 0 5 )。经时序检验E cadherin与甲状腺乳头状腺癌病人的预后并未表现出明显的相关关系。结论 :在大多数甲状腺乳头状腺癌中上皮细胞表面的E cadherin有一定的破坏 ,其淋巴结转移的发生与E cadherin的减少或功能的不正常可能有着密切的关系
Objective: To study the expression of E cadherin in thyroid papillary adenocarcinoma and to explore whether it can become an independent prognostic factor in thyroid papillary adenocarcinoma. Methods: The expression of E cadherin in 40 cases of thyroid papillary adenocarcinoma, 10 cases of thyroid follicular adenoma and 10 cases of normal thyroid tissue were studied by immunohistochemistry. The related factors that may influence the prognosis of thyroid cancer Tested by single factor survival analysis. Results: Nine cases (25.5%) had positive expression of E cadherin in thyroid papillary adenocarcinoma, most of them were undetectable or weakly positive, while 20 cases of benign thyroid carcinoma were positive (P <0.05). ). The positive rate of lymph node metastasis in 17 cases (59%) was significantly lower than that in non-lymph node metastasis (34.78%) (P <0.05). Time series test E cadherin and thyroid papillary adenocarcinoma patients did not show a significant correlation between the prognosis. Conclusion: E cadherin on the surface of epithelial cells in some thyroid papillary adenocarcinomas has some damage. The occurrence of lymph node metastasis may be closely related to the decrease or dysfunction of E cadherin