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研究了应用D001强酸性阳离子交换树脂作为催化剂合成维生素B1的新方法。方法以硫羟硫胺为原料,双氧水氧化生成硫酸维生素B1,再经过一定量的D001强酸性阳离子交换树脂处理,经稀盐酸洗脱浓缩、结晶至成品。研究了树脂用量、树脂温度、纯化水的稀释浓度、洗脱液浓度和催化剂的重复使用性能对反应的影响。通过试验确定可以利用D001大孔型强酸性阳离子交换树脂合成维生素B1,该工艺简化了操作,改善了环境污染,更重要的是提升了产品质量和收率。
A new method of synthesizing vitamin B1 by using D001 strong acid cation exchange resin as a catalyst was studied. Methods Thiokiothiamine was used as raw material to oxidize hydrogen peroxide to vitamin B1, and then treated with a certain amount of D001 strong acid cation exchange resin. The product was concentrated by dilute hydrochloric acid and crystallized to the final product. The effects of resin dosage, resin temperature, dilution concentration of purified water, concentration of eluent and reusability of catalyst on the reaction were studied. Through the test to determine the use of D001 macroporous strongly acidic cation exchange resin synthesis of vitamin B1, the process simplifies the operation and improve environmental pollution, more importantly, enhance product quality and yield.