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目的 观察心肌局部血管紧张素Ⅱ (ATⅡ )的活性及其受体 (ATR)的变化 ,探讨其在糖尿病性心肌病发生中的作用。方法 实验动物Wistar大鼠被分为 3个月对照组 (8只 )和糖尿病组 (8只 ) ;6个月对照组 (10只 )、糖尿病组 (10只 )和Losartan治疗组 (10只 ) ,分别于造模后 3个月、6个月检测心功能、ATⅡ及其受体的相关参数。结果 糖尿病组动物 3个月时首先出现 -dp/dtmax减低 ,血浆ATⅡ增高 ,6个月时 +dp/dtmax、-dp/dtmax均减低 ,心脏重量指数持续增加 ,心肌和血浆ATⅡ明显增高 ;心肌细胞膜ATⅡ受体亲和力明显增高 ;治疗组 +dp/dtmax、-dp/dtmax及心脏重量指数较糖尿病组均有所改善 ,心肌和血浆ATⅡ变化不明显。结论 ATⅡ及ATR的变化在糖尿病性心肌病发生中起重要作用
Objective To observe the changes of the activity of AT Ⅱ and its receptor (ATR) in myocardium and to explore its role in the pathogenesis of diabetic cardiomyopathy. Methods Wistar rats were divided into three groups: control group (n = 8), diabetes group (n = 8), control group (n = 10), diabetes group (n = 10) and Losartan treatment group , Respectively, at 3 months after modeling, 6 months to detect cardiac function, AT Ⅱ and its receptors related parameters. Results In the diabetic group, the -dp / dtmax decreased and the plasma ATⅡ increased at 3 months. The levels of + dp / dtmax and -dp / dtmax decreased at 6 months. The cardiac weight index increased continuously and the myocardial and plasma ATⅡ increased significantly. The AT II receptor affinity of the cell membrane was significantly increased; the dp / dtmax, -dp / dtmax and the cardiac weight index of the treatment group were all improved compared with those of the diabetic group, while the changes of ATⅡ in myocardium and plasma were not obvious. Conclusion The changes of AT Ⅱ and ATR play an important role in the pathogenesis of diabetic cardiomyopathy