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目的:研究~(~(99))锝-亚甲基二磷酸盐(~(99)Tc-MDP)对胶原诱导性关节炎大鼠血清TNF-α和IL-6的影响。方法:建立大鼠胶原诱导性关节炎模型,设生理盐水对照组、模型组、阳性药雷公藤多苷组、~(99)Tc-MDP治疗组,6周后大鼠麻醉颈总动脉取血,进行血清TNF-α和IL-6的检测,观察~(99)Tc-MDP对胶原诱导性关节炎大鼠的血清TNF-α和IL-6的影响。结果:~(99)Tc-MDP组、雷公藤多苷组对模型大鼠血清TNF-α和IL-6的有明显降低作用(P<0.05),并且~(99)Tc-MDP组疗效优于雷公藤多苷组(P<0.05)。结论:~(99)Tc-MDP能明显降低胶原诱导性关节炎大鼠血清TNF-α和IL-6表达。
Objective: To investigate the effect of 99Tc-methylene diphosphate (~ (99) Tc-MDP) on serum TNF-α and IL-6 in collagen-induced arthritis rats. Methods: The model of collagen-induced arthritis in rats was established. The normal saline control group, the model group, the positive drug tripterygium glycosides group, the ~ (99) Tc-MDP treatment group, The serum levels of TNF-α and IL-6 were measured. The effect of 99 Tc-MDP on serum TNF-α and IL-6 in collagen-induced arthritis rats was observed. Results: The group of ~ (99) Tc-MDP and tripterygium glycosides significantly reduced the levels of serum TNF-α and IL-6 in model rats (P <0.05), and the effect of ~ (99) Tc-MDP Tripterygium glycosides group (P <0.05). CONCLUSION: ~ (99) Tc-MDP can significantly decrease the serum levels of TNF-α and IL-6 in collagen-induced arthritis rats.