论文部分内容阅读
目的 探讨血栓弹力图和凝血指标D-二聚体以及炎症相关因子 (CRP、PCT) 在诊断重症肺炎合并脓毒症患者的临床效果.方法 选取2015年3月～2016年10月于我院就诊的重症肺炎合并脓毒症患者60例为研究组, 同期的60例体检正常者为对照组.所有参与对象均测量TEG参数 (包含R值、K值、α角、MA值、CI值) 及凝血指标D-二聚体和炎症因子 (CRP、PCT) 水平.结果 与正常对照组相比, 研究组R值、K值明显减小, α角、MA值、CI值明显增大, 血浆D-二聚体、CRP、PCT水平均明显升高, 差异均有统计学意义.TEG的参数与血浆D-二聚体、CRP、PCT水平具有相关性.结论 血栓弹力图联合D-二聚体、CRP、PCT在重症肺炎合并脓毒症患者血液高凝状态的检测中具有很好的实用意义, 并具有一定互补性.“,”Objective To investigate the clinical effect of thrombus elastography, coagulation related index D-dimer and inflammatory related cytokines (CRP, PCT) in the diagnosis of severe pneumonia complicated with sepsis.Methods Sixty patients with severe pneumonia complicated with sepsis treated in our hospital from March 2015 to October 2016 were selected as the study group, and 60 healthy subjects were selected as the control group in the same period.TEG parameters (including R value, K value, α angle, MA value and CI value), content of coagulation related index D-dimer and inflammatory related cytokines (CRP, PCT) were measured in all participants.Results Compared with the normal control group, the values of R and K in the study group decreased significantly, while the angles α, MA and CI increased significantly.The levels of plasma D-dimer, CRP and PCT in study group were significantly increased.And the parameters of TEG were related to content of coagulation related index (D-dimer, CRP, PCT).Conclusion Thrombelastography and coagulation related index (D-dimer, CRP, PCT) have great practical significance in the detection of hypercoagulable state in patients with severe pneumonia complicated with sepsis, and have some complementarity.