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癌细胞的永生化是肿瘤细胞区别于正常细胞的基本特征 ,也是肿瘤生长、浸润和转移的基础。端粒的发现由来已久 ,随着人们对端粒认识的深化 ,特别是 1989年Ｍｏｒｉｎ首先在人的癌细胞系中发现端粒酶以来 ,肿瘤细胞永生化的“端粒—端粒酶”学说已为越来越多的研究结果所证实。端
Immortalization of cancer cells is a basic feature that differentiates tumor cells from normal cells and is also the basis for tumor growth, invasion and metastasis. Telomere has been discovered for a long time. With the deepening of people’s understanding of telomere, especially since Morin first discovered telomerase in human cancer cell line in 1989, tumor cell immortalized telomere-telomerase Doctrine has been confirmed by more and more research results. end