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胰腺癌为恶性程度极高的消化系肿瘤,其死亡率占我国恶性肿瘤的第6位,在美国位于第4位。近年来,胰腺癌的发病率呈上升趋势,5年生存率仍很低,在诊断后的中位生存期为4～6月[1]。传统的治疗方法以手术、化疗、放疗为主,但随着胰腺癌发生分子机理研究的深入,人们有可能从基因水平对其进行治疗。本文就近年来胰腺癌的基因治疗现状、进展、存在的问题和未来前景作一综述。
Pancreatic cancer is a highly malignant tumor of the digestive system, its death rate accounts for the sixth of malignant tumors in our country, located in the United States No. 4. In recent years, the incidence of pancreatic cancer is on the rise, 5-year survival rate is still low, the median survival after diagnosis of 4 to 6 months [1]. The traditional treatment methods are surgery, chemotherapy and radiotherapy, but with the further study of the molecular mechanism of pancreatic cancer, it is possible to treat them at the gene level. This review summarizes the current status, progress, existing problems and future prospects of gene therapy in pancreatic cancer in recent years.