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目的:研究血浆同型半胱氨酸(Hcy)及其代谢因子叶酸(FA)、维生素B12(VitB12)水平与子痫前期(PE)患者病情严重程度的相关性。方法:测定70例正常晚期妊娠(对照组)、72例轻度PE(轻度PE组)、66例重度PE(重度PE组)患者的血浆Hcy水平及血清FA、VitB12水平。结果:对照组及轻、重度PE组的Hcy水平分别为(8.950±0.585)μmol/L、(11.116±0.615)μmol/L和(14.648±0.620)μmol/L,两两比较均有显著差异(P<0.05)。轻、重度PE组的FA水平显著低于对照组[(5.075±0.391)ng/ml、(4.488±0.280)ng/ml vs(6.245±0.465)ng/ml,P<0.05],而前两组则无显著差异(P>0.05);轻度PE组的VitB12水平显著低于对照组、重度PE组[(161.42±9.589)pg/ml vs(207.24±9.589)pg/ml、(202.12±10.361)pg/ml,P<0.05],而后两组则无显著差异(P>0.05)。血清FA水平与血浆Hcy水平呈负相关(r=-0.204,P=0.03),与血清VitB12水平呈正相关(r=0.204,P=0.03)。血浆Hcy水平与PE患者的病情严重程度呈正相关(r=0.450,P<0.001),血清FA水平与PE患者的病情严重程度呈负相关(r=-0.216,P=0.002)。结论:随着PE患者的病情加重,Hcy水平呈升高趋势,而FA呈下降趋势。FA与Hcy水平呈负相关。
Objective: To study the relationship between plasma homocysteine (Hcy), folic acid (FA) and vitamin B12 (vitamin B12) and the severity of preeclampsia (PE). Methods: Plasma Hcy, serum FA and VitB12 levels were measured in 70 patients with normal late pregnancy (control group), 72 with mild PE (mild PE group) and 66 with severe PE (severe PE group). Results: The levels of Hcy in the control group and the mild and severe PE groups were (8.950 ± 0.585) μmol / L, (11.116 ± 0.615) μmol / L and (14.648 ± 0.620) μmol / L, P <0.05). FA levels in the mild and severe PE groups were significantly lower than those in the control group [(5.075 ± 0.391) ng / ml, (4.488 ± 0.280) ng / ml vs (6.245 ± 0.465) ng / ml, (P <0.05). The levels of VitB12 in mild PE group were significantly lower than those in control group (P <0.001) pg / ml, P <0.05], but there was no significant difference between the latter two groups (P> 0.05). Serum FA level was negatively correlated with plasma Hcy level (r = -0.204, P = 0.03), and positively correlated with serum VitB12 level (r = 0.204, P = 0.03). Plasma Hcy level was positively correlated with the severity of PE (r = 0.450, P <0.001). The level of serum FA was negatively correlated with the severity of PE (r = -0.216, P = 0.002). CONCLUSIONS: With the aggravation of PE patients, the level of Hcy is increasing while that of FA is decreasing. FA and Hcy levels were negatively correlated.