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【目的】观察术前静脉给予氢化泼尼松对2型糖尿病（T2DM ）妇科腹腔镜手术患者围术期血糖的影响。【方法】60例择期全麻下行妇科腹腔镜手术患者分为三组，每组20例：T2DM 患者氢化泼尼松处理组（A组）、非糖尿病患者氢化泼尼松处理组（B组）和T2DM患者生理盐水组（C组）。麻醉诱导前30 min ，A组和B组患者静脉予氢化泼尼松10 mg ，C组予生理盐水2 mL。记录给药前（T0），给药后1 h（T1）、2 h（T2）、3 h （T3）、4 h（T4）血糖，T4时VAS评分及术后恶心呕吐的发生例数。【结果】三组患者一般情况组间比较无明显差异（ P ＞0．05）。A组患者T0时血糖高于B组患者（ P ＜0．05）。与T0比较，A组患者T1～T4，B组T2～T3，S组T3～T4时血糖明显增高（ P＜0．05）。与B组比较，A组T3血糖较高；与C组比较，A组患者 T1～T3血糖较高（ P ＜0．05）。与C组比较，A组和B组患者 T4时VAS评分、术后恶心呕吐发生率较低（ P ＜0．05）。【结论】氢化泼尼松可升高妇科腹腔镜患者围术期血糖，对T2DM患者尤为明显，但均在安全范围内。“,”Objective] To explore the effects of hydroprednisolone on blood glucose in patients during gy‐necological laparoscopy .[Methods]A total of 60 elective gynecological laparoscopic patients were selected and divided into 3 groups of type 2 diabetes mellitus (T2DM) patients with hydroprednisolone (A) ,non‐diabetics with hydroprednisolone (B) and type 2 diabetics with saline (C) ( n=20 each) .At 30 min pre‐induction ,10 mg hydroprednisolone was injected intravenously for groups A and B while 2 ml normal saline for group C . Blood glucose levels were recorded at pre‐dosing (T0 ) and 1 h(T1 ) ,2 h (T2 ) ,3 h (T3 ) ,4 h (T4 ) post‐do‐sing .The visual analog scale (VAS) at T4 and the incidence of postoperative nausea and vomiting (PONV) was recorded and analyzed .[Results]No significant difference existed in general status among 3 groups ( P>0 .05) .The blood glucose level of T2DM was higher than non‐diabetes at T0 ( P <0 .05) .Compared with at T0 ,the levels of blood glucose increased significantly at T1~4 in group A ,T2~3 in group B and T3~4 in group C ( P <0 .05) .Compared with group C ,blood glucose levels at T1~3 were higher in group A and at T3 was higher in group B ( P<0 .05) .And VAS at T4 and the incidence of PONV were lower in groups A and B than those in group C ( P<0 .05) .[Conclusion] Hydroprednisolone can increase perioperative blood glucose in pa‐tients during gynecologic laparoscopy ,especially for T2DM .