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应用酒石酸锑钾与葡萄精酸锑~(Ⅲ)钠溶液的经口给药法,试治家兎血吸虫病,确有相当疗效。口服剂量虽较注射剂量分别加至九倍与四倍,但其疗效仍远不如注射法给药各组,而动物死亡率反较高。延长治程而酌减每次口服剂量,经口给药与静脉给药适当结合,仍不能提高其安全性。所试的酒石酸锑钾肠溶片在相同剂量时完全无效。口服锑剂的进一步研究应在吸收控制与剂型改进两方面努力。
The application of antimony potassium tartrate and grape antimony ~ (Ⅲ) sodium solution oral administration method, the experimental treatment of Schistosoma japonicum, does have a considerable effect. Although the oral dose than the injection dose were increased to nine times and four times, but its efficacy is still far less than the injection of each group, while animal mortality is higher. Prolonged course of treatment and reduce each oral dose, oral administration and appropriate combination of intravenous administration, still can not improve its safety. The test antimony potassium tartrate enteric-coated tablets at the same dose completely null and void. Further studies of oral antimony agents should work both in absorption control and dosage form improvement.