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目的观察活血降糖饮治疗代谢综合征的临床疗效并初步探讨其作用机理。方法将60例患者按照随机数字表法随机分为治疗组与对照组各30例。对照组给予基础治疗,治疗组在对照组基础上给予活血降糖饮服用,两组共治疗12 W。治疗前后分别观察FBG、P2hBG、FINS、TC、TG、HDL-C、LDL-C及hs-CRP表达。结果两组治疗后各项指标均有明显改善,与治疗前比较,差异有显著性(P<0.05或P<0.01),治疗后两组比较,P2hBG、FINS、TC、LDL-C及hs-CRP表达的差异有显著性(P<0.05),治疗组优于对照组。结论活血降糖饮能改善代谢综合征患者血糖、血脂水平,其作用可能与抑制hs-CRP的表达、改善胰岛素抵抗有关。
Objective To observe the clinical efficacy of Huoxuejiangtangyin in treating metabolic syndrome and to explore its mechanism. Methods Sixty patients were randomly divided into treatment group (n = 30) and control group (n = 30) according to random number table method. The control group was given basic treatment. The treatment group was given Huoxue Hypoglycemic Drink on the basis of the control group, and 12 W was treated in both groups. The levels of FBG, P2hBG, FINS, TC, TG, HDL-C, LDL-C and hs-CRP were observed before and after treatment. Results After treatment, the indexes of both groups were significantly improved (P <0.05 or P <0.01), and the levels of P2hBG, FINS, TC, LDL-C and hs- CRP expression was significantly different (P <0.05), the treatment group than the control group. Conclusion Huoxuejiangtangji decoction can improve blood glucose and lipid levels in patients with metabolic syndrome, which may be related to inhibiting the expression of hs-CRP and improving insulin resistance.