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目的:探讨卵泡期长效长方案对卵巢储备功能良好但前次黄体期短效长方案助孕失败患者的妊娠结局是否有所改善。方法:回顾性分析106例前次黄体期短效长方案助孕失败后行卵泡期长效长方案再次助孕的卵巢储备功能良好(AFC>5)患者212个周期的临床资料,按照促排卵方案分为黄体期短效长方案(A组)与卵泡期长效长方案(B组)。结果:Gn启动日E2值、hCG注射日E2值和子宫内膜厚度以及移植胚胎数组间比较均无统计学差异(P>0.05)。B组Gn启动日、hCG注射日血LH值和早期流产率均显著低于A组(P<0.001),而Gn使用总剂量、Gn使用天数、获卵数、MII卵数、MII卵率、2PN数、可移植胚胎数、胚胎种植率、生化妊娠及临床妊娠率均显著高于A组(P<0.001)。结论:在卵巢储备功能良好但前次黄体期短效长方案助孕失败的女性中,再次助孕采用卵泡期长效长方案可显著提高获卵数及卵子质量,并显著提高妊娠率,降低早期流产率,是理想的治疗方案。
OBJECTIVE: To investigate if the long-term follicular phase regimen improved pregnancy outcome in patients with poor ovarian reserve but with short-term long-term progestational programs in the luteal phase. Methods: The clinical data of 212 cycles with well-preserved ovarian reserve (AFC> 5) in 106 patients with failed prolactin after the previous luteal phase shortening of pregnancy were retrospectively analyzed. According to the data of ovulation induction Program is divided into luteal phase short-acting long program (A group) and long-term follicular phase of the long-term program (B group). Results: There was no significant difference in E2 value at Gn start-up day, E2 value at end of hCG injection, endometrial thickness and the number of transplanted embryos (P> 0.05). The Gn start-up day, blood LH value and early miscarriage rate on the day of hCG injection in group B were significantly lower than those in group A (P <0.001), while the total dose of Gn, number of Gn days, number of oocytes retrieved, number of MII oocytes, 2PN number, number of transplantable embryos, embryo implantation rate, biochemical pregnancy and clinical pregnancy rate were significantly higher than those in group A (P <0.001). CONCLUSIONS: In women with good ovarian reserve but failed to contribute to pregnancy with short-term luteal short-term regimen, the long-term follicular-phase regimen can significantly increase the number of oocytes and the egg quality and significantly improve the pregnancy rate and reduce the pregnancy rate Early abortion rate, is the ideal treatment.