德国研究人员仿造了用于SARS病毒复制的主要蛋白酶,以促进快速寻找有效的治疗手段。这种酶的结构提示,目前正在开发的抗鼻病毒药物——AG7088,事实上可减轻新型冠状病毒所引起的SARS病情。 吕贝克大学Hilgenfeld博士等在首次从猪冠状病毒和人冠状病毒229E中确定的同功酶结构的基础上,建立了主要的SARS病毒蛋白酶模型。他们 German researchers mimic the major proteases used for SARS virus replication to facilitate the rapid search for effective treatments. The structure of this enzyme suggests that the anti-rhinovirus drug currently being developed, AG7088, actually alleviates the SARS-related illness caused by the novel coronavirus. Hügenfeld, Ph.D., Lübeck University, founded the first SARS virus protease model based on the first isozyme structure determined from porcine coronavirus and human coronavirus 229E. they