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对羟基苯甲酸酯类物质广泛用做食品、药品、化妆品防腐剂,近年国外的研究表明,对羟基苯甲酸酯类物质引起雌性大、小鼠子宫重量增加,影响雄性动物睾丸晚期精子发生,降低仔鼠活产比例与体重,使雄性仔鼠附睾精子数、精子活动度降低。对羟基苯甲酸酯类物质能抑制[3H]17β-雌二醇([3H]E2)与雌激素受体(ER)的结合,并引起两种雌激素依赖细胞株MCF-7和ZR-75-1的增殖,增加MCF-7细胞转染(ERE-CAT受体基因)和内源性(pS2)基因的表达,显示该类物质有弱雌激素活性。
Parabens are widely used as food, medicine and cosmetic preservatives. In recent years, foreign studies have shown that parabens cause female large mouse uterus weight increase, affecting the late male testicular spermatogenesis, decreased Offspring live birth ratio and body weight, so that male offspring sperm count, sperm motility decreased. Parabens inhibited the binding of [3H] 17β-estradiol ([3H] E2) to the estrogen receptor (ER) and caused two estrogen-dependent cell lines, MCF-7 and ZR-75 -1, increase the expression of ERE-CAT receptor gene and endogenous gene (pS2) in MCF-7 cells, indicating weak estrogen activity.