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目的:研究母孕期暴露于氯氮平或其他非典型抗精神病药对后代躯体和智能发育影响的差异。方法:招募孕期服用氯氮平或其他非典型抗精神病药的孕妇各20名,其后代出生后随访12个月。后代躯体发育指标为Ap-gar评分、身高和体重。智能发育指标为贝利婴幼儿发育量表-第三版评分。结果:两组儿童躯体发育指标间的差异均无显著性。智能发育指标中,两组儿童认知和适应行为评分的差异始终无显著性;氯氮平组在2月和6月的语言和运动评分显著低于对照组(P均<0.05),但12月时,两组差异无显著性;氯氮平组儿童在各测评时点社交情感的评分均显著低于对照组(P均<0.05)。结论:孕期暴露于氯氮平对后代早期智能发育的不良影响较大,部分影响会持续到出生后12个月。
OBJECTIVE: To investigate the differences in the physical and intellectual development of offspring between exposure to clozapine or other atypical antipsychotics during the first trimester of pregnancy. METHODS: Twenty pregnant women were recruited during pregnancy to receive clozapine or other atypical antipsychotics, and their offspring were followed up for 12 months after birth. The offspring physical development indicators Ap-gar score, height and weight. Intelligent developmental indicators for the Bailey infant development scale - third edition score. Results: There was no significant difference in somatic development between the two groups. There was no significant difference in cognitive developmental and adaptive behavior scores between the two groups in the indicators of mental development. The language and exercise scores of the clozapine group in February and June were significantly lower than those in the control group (all P <0.05), but 12 Month, there was no significant difference between the two groups. Children in clozapine group had significantly lower scores of social emotion at each evaluation point than those in control group (all P <0.05). CONCLUSIONS: Exposure to clozapine during pregnancy has a detrimental effect on the early intelligence development of offspring, and some effects persist to 12 months after birth.