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目的探讨奥美拉唑联合伊托必利治疗反流性食管炎的临床疗效。方法选取攀枝花市仁和区人民医院2014年9月—2016年7月收治的反流性食管炎患者156例,随机分为对照组和研究组,每组78例。对照组患者采用法莫替丁联合伊托必利治疗,研究组患者采用奥美拉唑联合伊托必利治疗,两组患者均持续治疗2个疗程。比较两组患者治疗前后临床症状(呕吐恶心、反酸、胸口烧灼感)积分及临床疗效,观察患者药物不良反应发生情况。结果治疗前,两组患者呕吐恶心、反酸、胸部烧灼感积分比较,差异无统计学意义(P>0.05);治疗后,研究组患者呕吐恶心、反酸、胸部烧灼感积分低于对照组(P<0.05)。研究组患者总有效率高于对照组(P<0.05)。两组患者治疗期间均未发生药物不良反应。结论采用奥美拉唑联合伊托必利治疗反流性食管炎的临床疗效确切,可有效改善患者的临床症状,且安全性高。
Objective To investigate the clinical efficacy of omeprazole combined with itopride in the treatment of reflux esophagitis. Methods 156 patients with reflux esophagitis who were treated in Renhe District People’s Hospital of Panzhihua City from September 2014 to July 2016 were randomly divided into control group and study group, 78 cases in each group. Patients in the control group were treated with famotidine combined with itoprime. Patients in the study group were treated with omeprazole combined with itopril. Patients in both groups were treated continuously for 2 courses. The clinical symptoms (vomiting nausea, acid reflux, chest burning sensation) score and clinical efficacy before and after treatment were compared between two groups to observe the adverse drug reactions in patients. Results Before treatment, vomiting nausea, acid reflux and chest burning sensation scores were not significantly different between the two groups (P> 0.05). After treatment, the vomiting nausea, acid reflux and chest burning sensation scores of the study group were lower than those of the control group (P <0.05). The total effective rate of study group was higher than that of control group (P <0.05). Two groups of patients during treatment did not occur adverse drug reactions. Conclusion Omeprazole combined with itopride in the treatment of reflux esophagitis clinical efficacy is exact, can effectively improve the patient’s clinical symptoms, and high safety.