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目的研究放射治疗联合奥沙利铂与卡培他滨治疗局部晚期直肠癌的疗效及不良反应。方法选择局部晚期直肠癌患者84例作为研究对象。采用随机分组法分为观察组和对照组,每组42例。观察组采用放射治疗联合奥沙利铂与卡培他滨化疗方案,对照组给予单纯奥沙利铂与卡培他滨化疗方案,对比两组疗效。结果观察组近期疗效的总有效率为78.57%,显著高于对照组(47.62%),差异有统计学意义(P<0.05)。观察组局部复发率低于对照组,保肛率及生存率均高于对照组,但差异未见统计学意义(P>0.05)。两组恶心呕吐、腹泻、白细胞降低、手足综合征及神经毒性发生情况比较差异未见统计学意义(P>0.05)。结论三维适形放射治疗联合奥沙利铂与卡培他滨治疗局部晚期直肠癌患者近期疗效显著,不良反应均为耐药,是一种安全、可靠、便捷的治疗方案,值得临床推荐。
Objective To study the efficacy and side effects of radiotherapy combined with oxaliplatin and capecitabine in the treatment of locally advanced rectal cancer. Methods 84 patients with locally advanced rectal cancer were selected as the research object. Randomized divided into observation group and control group, 42 cases in each group. The observation group received radiotherapy combined with oxaliplatin and capecitabine chemotherapy, while the control group received oxaliplatin and capecitabine chemotherapy alone. The efficacy of the two groups was compared. Results The total effective rate of the observation group was 78.57%, significantly higher than that of the control group (47.62%), the difference was statistically significant (P <0.05). The local recurrence rate in the observation group was lower than that in the control group, and the anus retention rate and survival rate were higher than those in the control group, but the difference was not statistically significant (P> 0.05). Nausea and vomiting in both groups, diarrhea, leukopenia, hand-foot syndrome and neurotoxicity showed no significant difference (P> 0.05). Conclusion Three-dimensional conformal radiotherapy combined with oxaliplatin and capecitabine in the treatment of locally advanced rectal cancer patients with significant short-term effects, adverse reactions are resistant, is a safe, reliable and convenient treatment, it is worth clinical recommendation.