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目的 探讨胆囊胆汁癌胚抗原 (CEA)值诊断大肠癌肝转移的临床价值。方法 应用竞争放射免疫分析法共测定胆囊胆汁及同期血清CEA值 75例。共分为三组 :A组 (大肠癌组 ) 34例、B组 (术后肝转移组 ) 11例、C组 (良性疾病组 )为对照组 30例。胆汁标本于术中细针穿刺胆囊抽取 5ml ,血清标本于术晨采集静脉血 2ml。结果 胆汁CEA测定结果 :A组均值 ( 173 2± 2 5)ng ml;B组均值 ( 752± 117)ng ml;C组均值 ( 4 1 3± 2 8)ng ml。经统计学处理 ,A、B与C组比较有显著性差异P <0 0 1,A与B组比较有显著性差异P <0 0 1。血清CEA测定结果 :A组均值 ( 17 3± 2 7)ng ml;B组均值 ( 19 5± 4 3)ng ml ;C组均值 ( 11 3± 1 4 )ng ml。经统计学处理 ,A、B与C组比较有明显差异P <0 0 5。A与B组比较无明显差异P >0 0 5。结论 胆囊胆汁CEA值 >640ng ml时对诊断大肠癌肝转移有一定临床意义。
Objective To investigate the clinical value of gallbladder carcinoembryonic antigen (CEA) in the diagnosis of liver metastasis of colorectal cancer. Methods 75 patients with gallbladder bile and the same period serum CEA value were measured by competitive radioimmunoassay. There were 34 cases in group A (colorectal cancer group), 11 cases in group B (postoperative liver metastasis group) and 30 cases in group C (benign disease group). Bile samples in the operation fine needle puncture gallbladder extraction 5ml, serum samples collected in the morning 2ml venous blood. Results The results of CEA determination of bile: mean of group A was (173 2 ± 25) ng ml; group B was (752 ± 117) ng ml; group C was (4 1 3 ± 2 8) ng ml. Statistically, there was a significant difference between A, B and C (P <0.01). There was significant difference between A and B (P <0.01). Serum CEA results were as follows: group A (17 3 ± 2 7) ng ml; group B mean (19 5 ± 4 3) ng ml; group C mean (113 ± 1 4) ng ml. Statistically, A, B and C groups were significantly different P <0 05. There was no significant difference between A and B group (P> 0.05). Conclusion Gallbladder bile CEA value> 640ng ml when the diagnosis of liver metastasis of colorectal cancer has some clinical significance.