绿脓杆菌是一种特别难以对付的病原体,较任何其他细菌引起的死亡率都高。由绿脓杆菌引起的菌血症、肺炎、骨髓炎和心内膜炎的死亡率显著高于其他细菌病原体。此外,有许多抗菌药物在体外有抗绿脓杆菌的作用。对绿脓杆菌的抗生素选择较其他病原体复杂,尚存在以下问题:(1)体外敏感性和协同作用试验缺乏标准化与结果的变异性;(2) Pseudomonas aeruginosa is a particularly unmanageable causative agent and causes more mortality than any other bacterium. Bacteremia caused by Pseudomonas aeruginosa, pneumonia, osteomyelitis and endocarditis mortality was significantly higher than other bacterial pathogens. In addition, many antimicrobials have anti-Pseudomonas aeruginosa effects in vitro. The selection of antibiotics for Pseudomonas aeruginosa is more complex than other pathogens, with the following problems: (1) lack of standardization and variability of results in in vitro susceptibility and synergistic trials; (2)