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利用早熟染色体凝集技术预测研究了γ射线对肝癌细胞SMMC7721的辐射效应。结果表明,G1和G2期细胞内的染色单体和等点染色单体断裂数与照射剂量之间存在线性相关性,染色单体断裂总数与细胞存活率之间存在良好的线性相关性。说明辐射诱导的染色单体断裂可以作为预测SMMC7721细胞内在辐射敏感性的指标,也可为临床诊断和治疗肝癌提供依据。
The precocious chromosome agglutination technique was used to predict the radiation effects of γ-rays on SMMC7721 hepatoma cells. The results showed that there was a linear correlation between the number of chromatid and isodose dying cells and irradiation dose in G1 and G2 cells, and there was a good linear correlation between the total number of chromatid breaks and cell survival rate. It indicates that the radiation-induced chromatid fragmentation can be used as an index to predict the intrinsic radiation sensitivity of SMMC7721 cells and provide a basis for clinical diagnosis and treatment of liver cancer.