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利用从患者体内分离的特异性免疫复合物 (IC)和人工特异性 IC对 72例结核病患者补体介导的免疫复合物溶解能力 (CMSC)进行了研究。结果 ,正常对照组循环免疫复合物 (CIC)水平为 0 .0 98± 0 .0 37,患者组中浸润型、纤维空洞型、粟粒型肺结核、肺外结核分别为 0 .2 0 1±0 .0 74、0 .1 99± 0 .0 36、0 .1 62± 0 .0 77、0 .1 4 4± 0 .0 70 ;活动性结核病为 0 .1 88± 0 .0 4 5,与正常对照组相比均明显升高 (P<0 .0 0 1 )。各种 IC解离剂对 CIC均有明显裂解作用 ,且与原 CIC水平相平行。CMSC正常对照为 0 .39± 0 .0 9μg,各类结核病患者依次为 0 .1 5± 0 .1 2 μg、0 .1 8± 0 .1 0 μg、0 .1 7± 0 .0 8μg、0 .31± 0 .1 3μg、0 .2 0± 0 .1 1 μg,均明显低于正常对照 (P<0 .0 5～ 0 .0 0 1 )。患者补体成分C3 、C4亦有一定改变。研究结果表明 :1结核病患者血清中存在高水平的 CIC,其中主要为特异性IC;2患者 CMSC补体新功能明显降低 ,但各类病人中降低程度有所不同 ,CMSC低下是结核病发病的原因之一 ;3补体成分缺失与 CMSC的功能降低有一定关系。
72 cases of tuberculosis patients with complement-mediated immune complex lysis (CMSC) were studied using specific immune complexes (ICs) isolated from patients and artificial-specific ICs. The results showed that the level of circulating immune complex (CIC) in the normal control group was 0.098 ± 0.37, and the infiltration type, fibrous cavity type, miliary tuberculosis and extra-pulmonary tuberculosis in the control group were respectively 0.201 ± 0 .0 74,0 .1 99 ± 0 .0 36,0 .1 62 ± 0 .0 77,0 .1 4 4 ± 0 .0 70; active tuberculosis was 0.18 ± 0. 0 4 5, Compared with the normal control group were significantly increased (P <0. 001). A variety of IC dissociation agent CIC obvious cleavage, and parallel with the original CIC level. CMSC normal control was 0.39 ± 0. 09μg, all kinds of tuberculosis patients were followed by 0 1 1.5 ± 0. 1 2 μg, 0 1 8 ± 0 1 0 μg, 0 1 7 ± 0 0 8 μg , 0 .31 ± 0 .1 3μg, 0 .2 ± 0 .1 1 μg, were significantly lower than the normal control (P <0.05 ~ 0. Complement C3, C4 patients also have some changes. The results showed that: 1 There is a high level of CIC in the serum of patients with tuberculosis, which is mainly specific IC; 2 patients significantly reduced the new function of complement of CMSC, but the degree of reduction is different in all kinds of patients, CMSC low is the cause of tuberculosis A; 3 complement component loss and reduce the function of CMSC have a certain relationship.