论文部分内容阅读
植物聚酮合酶催化起始底物(酰基辅酶A)反复地与丙二酰辅酶A进行缩合,通过C—C键的形成生成链状聚酮中间体,再经Claisen环合、Aldol环合等形式并经芳香化生成结构新颖多样的天然产物及“非天然小分子”.对近年来发现的植物聚酮合酶的功能及来源、催化机制以及在合成“非天然小分子”中的应用进行综述.
The plant polyketide synthase catalyzes the initial substrate (acyl-CoA) to repeatedly condense with malonyl-CoA to form a chain polyketide intermediate by the formation of a C-C bond followed by Claisen cyclization and Aldol cyclization And other forms of aromatic and generate a variety of new and diverse natural products and “non-natural small molecules ” on the plant polyketide synthase found in recent years, the function and source of the catalytic mechanism and synthesis “non-natural small molecule ”In the application review.