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目的:观察健骨蠲痹胶囊的抗炎镇痛作用。方法:采用弗氏完全佐剂致大鼠足肿胀法、巴豆油致小鼠耳肿胀法、棉球致大鼠肉芽肿法评价药物的抗炎作用;采用扭体法和热板致痛法评价药物的镇痛作用。结果:健骨蠲痹胶囊能显著抑制佐剂性关节肿胀,显著减轻巴豆油所致小鼠耳肿胀,减少大鼠棉球肉芽肿的形成。健骨蠲痹胶囊对醋酸及热刺激诱发小鼠的疼痛均具显著的抑制作用。结论:健骨蠲痹胶囊具有抗炎和镇痛作用。
Objective: To observe the anti-inflammatory and analgesic effect of Jianguobubi capsule. Methods: The anti-inflammatory effects of drugs were evaluated by Freund’s complete adjuvant-induced rat paw edema, rat ear edema induced by croton oil and rat granuloma caused by cotton ball. The writhing and hot plate pain were used to evaluate the anti- Drug analgesic effect. Results: Jiangujubi capsule can significantly inhibit the swelling of adjuvant joints, significantly reduce ear swelling induced by croton oil and reduce the formation of cotton ball granuloma in rats. Jiangujubi capsule on acetic acid and heat-induced pain in mice were significantly inhibited. Conclusion: Jiangyoubibi Capsule has anti-inflammatory and analgesic effects.