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目的探讨胃舒胶囊结合西药治疗功能性消化不良伴抑郁症的临床疗效。方法将65例功能性消化不良伴抑郁症的患者随机分为治疗组(35例)和对照组(30例),对照组给予多潘立酮片和黛力新治疗,治疗组在对照组用药基础上加服中药制剂胃舒胶囊;两组疗程均为6周,观察临床疗效及临床症状评分、HAMD量表评分变化情况。结果治疗组与对照组总有效率分别为91.42%、33.33%;组间临床疗效比较,差异有统计学意义(P<0.01)。治疗组治疗前后组内比较,临床症状评分及HAMD量表评分差异均有统计学意义(P<0.05,P<0.01);对照组治疗前后组内比较,各指标评分差异均无统计学意义(P>0.05);组间治疗后比较,各指标评分差异均有统计学意义(P<0.05,P<0.01)。结论胃舒胶囊能明显提高功能性消化不良伴抑郁症的临床疗效。
Objective To investigate the clinical efficacy of Weishu capsule combined with western medicine in the treatment of functional dyspepsia with depression. Methods Sixty-five patients with functional dyspepsia and depression were randomly divided into treatment group (n = 35) and control group (n = 30). The control group was given domperidone tablets and Deanxit. The patients in the control group received Chinese medicine preparation stomach capsule; two courses were 6 weeks, observe the clinical efficacy and clinical symptom scores, HAMD scale score changes. Results The total effective rates of the treatment group and the control group were 91.42% and 33.33% respectively. There was significant difference between the two groups in clinical efficacy (P <0.01). Before and after treatment in the treatment group, clinical symptom scores and HAMD scale scores were significantly different (P <0.05, P <0.01); in the control group before and after treatment, there was no significant difference in each index P> 0.05). After treatment, the scores of each index were statistically significant (P <0.05, P <0.01). Conclusion Weishu capsule can significantly improve the clinical efficacy of functional dyspepsia with depression.