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目的探讨直接法检测稽留流产患者绒毛染色体的应用价值与方法评价。方法通过直接法绒毛染色体核型分析检测229例稽留流产患者绒毛染色体,其中胚胎期稽留流产组132例,胎儿期稽留流产组97例;非高龄组185例,高龄组44例。结果直接法绒毛染色体检测成功率为61.6%(141/229),核型异常率为56.0%。染色体异常的类型以常染色体三体发生率最高,占异常核型的35.4%(28/79)。胚胎期稽留流产组中绒毛标本检测成功率与胎儿期稽留流产组有显著差异(P<0.05);非高龄组染色体核型异常率与高龄组没有显著差异(P>0.05)。结论直接法检测绒毛染色体核型检出率较低,更适合于胚胎期稽留流产患者。
Objective To investigate the value and method evaluation of villus chromosomes in direct abortion patients with missed abortion. Methods The chromosomal aberrations of 229 missed abortion patients were detected by direct karyotype analysis of karyotype. Among them, 132 were aborted with embryo abortion, 97 were aborted by fetus in fetus, 185 were non-elder and 44 were elder. Results The success rate of chromosomal detection by direct method was 61.6% (141/229), and the abnormal rate of karyotype was 56.0%. Chromosomal abnormalities in the highest incidence of autosomal trisomy, accounting for 35.4% (28/79) of abnormal karyotype. The success rate of detection of villus specimens in embryo aborted abortion group was significantly different from that of aborted abortion group (P <0.05). There was no significant difference in chromosomal karyotypes between non-senior group and advanced group (P> 0.05). Conclusion Direct detection of villus chromosome karyotype detection rate is low, more suitable for embryo abortion patients.