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目的 探讨非小细胞肺癌的骨转移规律和影响因素。方法 对638例非小细胞肺癌患者的骨转移情况进行统计分析。结果 非小细胞肺癌骨转移率为35.3%。多发转移者201例,全组平均病灶3.4个。骨转移的部位以胸部最常见,其它依次为脊柱、骨盆、肢体和颅骨,各组间比较有非常显著差异(P<0.005)。腺癌和腺鳞癌骨转移率明显高于鳞癌(P<0.005)。细胞分化程度较低者骨转移率明显增高(P<0.005)。Ⅲ～Ⅳ期骨转移率明显高于Ⅰ～Ⅱ期(P<0.005)。结论 肺癌骨转移临床常见,肺癌患者应常规作全身骨显像检查。骨显像检查有助于肺癌的准确分期和制定治疗方案
Objective To investigate the bone metastasis and its influencing factors in non-small cell lung cancer. Methods The bone metastases of 638 patients with non-small cell lung cancer were statistically analyzed. Results The bone metastatic rate of non-small cell lung cancer was 35.3%. There were 201 cases with multiple metastases, and the average group had 3.4 lesions. The site of bone metastases was the most common in the chest, followed by the spine, pelvis, limb, and skull, with very significant differences between the groups (P<0.005). The rate of bone metastasis was significantly higher in adenocarcinoma and adenosquamous carcinoma than in squamous carcinoma (P < 0.005). The rate of bone metastasis was significantly higher in patients with lower cell differentiation (P<0.005). The rate of bone metastasis in stage III-IV was significantly higher than stage I-II (P<0.005). Conclusion Bone metastases from lung cancer are common clinically. Lung cancer patients should be routinely used for whole body bone imaging examination. Bone scintigraphy helps accurate staging of lung cancer and formulate treatment plans