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目的探讨外周血淋巴细胞/单核细胞比值(LMR)与恶性胸膜间皮瘤(MPM)患者预后的关系。方法收集85例MPM患者的临床资料和随访资料,根据外周血LMR值将患者分为高LMR组(n=27)和低LMR组(n=58),对比分析两组临床病理资料和生存时间,并采用Cox回归模型分析LM R及其他临床病理因素与患者总生存期的关系。结果两组性别、功能状态(PS)评分、淋巴细胞计数和单核细胞计数差异有统计学意义(P<0.05)。高LMR组中位生存时间(27个月)显著长于低LMR组(9个月)(P<0.001)。在不同组织学类型和肿瘤分期患者中,高LMR组中位生存时间均长于低LMR组(P<0.05)。多因素分析显示,LMR是影响MPM患者总生存期的独立因素(HR:0.277;95%CI:0.142~0.538;P<0.001)。结论外周血LMR可作为反映MPM患者生存预后的生物学标志物。
Objective To investigate the relationship between the peripheral blood lymphocyte / monocyte ratio (LMR) and the prognosis of patients with malignant pleural mesothelioma (MPM). Methods The clinical data and follow-up data of 85 patients with MPM were collected. The patients were divided into high LMR group (n = 27) and low LMR group (n = 58) according to the LMR value of peripheral blood. The clinical and pathological data and survival time , And Cox regression model was used to analyze the relationship between LM R and other clinicopathological factors and overall survival. Results There were significant differences in gender, functional status (PS) score, lymphocyte count and monocyte count between the two groups (P <0.05). The median survival time (27 months) in the high LMR group was significantly longer than in the low LMR group (9 months) (P <0.001). Among patients with different histological types and tumor stage, the median survival time in high LMR group was longer than that in low LMR group (P <0.05). Multivariate analysis showed that LMR was an independent factor affecting the overall survival of patients with MPM (HR: 0.277; 95% CI: 0.142-0.538; P <0.001). Conclusion Peripheral blood LMR can be used as a biomarker to reflect the prognosis of MPM patients.