论文部分内容阅读
Ⅰ型脱碘酶为含硒酶。缺硒时，该酶活性下降，使循环Ｔ４水平增高，外周组织Ｔ３水平下降。缺硒可加速甲状腺组织碘的耗竭，并加重某些缺碘的生物学效应。缺硒还可能与碘缺乏病的发生发展有关。以缺硒为主要病因的克山病存在甲状腺激素代谢异常，其心肌呼吸酶活性变化与缺碘引起的甲状腺功能低下相似。缺碘或缺硒引起的甲状腺激素代谢改变与克山病的发生可能有关。
Type Ⅰ deiodinase enzyme containing selenium. Se deficiency, the enzyme activity decreased, so that increased circulating T4 levels, peripheral tissue T3 levels decreased. Selenium deficiency can speed up the depletion of thyroid iodine and aggravate the biological effects of some iodine deficiency. Selenium deficiency may also be related to the occurrence and development of iodine deficiency disorders. The main cause of selenium deficiency Keshan disease is the existence of thyroid hormone metabolism, changes in myocardial respiration enzyme activity and lack of iodine-induced hypothyroidism is similar. The lack of iodine or selenium-induced thyroid hormone metabolism and Keshan disease may be related.