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目的比较血液透析滤过和血液灌流串联血液透析对维持血透患者低血钙、高血磷、高血清甲状旁腺素的改善情况。方法将30例维持性血液析透患者随机分为2组,分别采用血液透析滤过(HDF)、血液灌流串联血液透析(HP+HD)连续治疗3个月后观察血钙、血磷及iPTH的变化。结果HDF组治疗后血磷降至(2.47±0.78)mmol/L,iPTH降至(312.54±98.5)pg/ml;HP+HD组治疗后血磷降至(1.77±0.2)mmol/L,iPTH降至(212±70.3)pg/ml;2组治疗后血磷及血iPTH水平均明显下降(P<0.05)。此外,HP+HD组血磷及iPTH清除率均明显大于HDF组(P<0.05)。结论HDF及HP+HD均能有效清除血磷和iPTH,而HP+HD更有效。
Objective To compare the effects of hemodiafiltration and hemoperfusion serial hemodialysis on the maintenance of hypocalcemia, hyperphosphatemia and hyperparathyroidism in hemodialysis patients. Methods Thirty patients with maintenance hemodialysis were randomly divided into two groups. The levels of serum calcium, phosphorus and iPTH were measured by continuous hemodialysis (HDF) and hemodialysis (HP + HD) for 3 months. The change. Results After treatment, serum phosphorus in HDF group decreased to (2.47 ± 0.78) mmol / L and iPTH decreased to (312.54 ± 98.5) pg / ml in HDF group, but decreased to (1.77 ± 0.2) mmol / L and To (212 ± 70.3) pg / ml, respectively. After treatment, serum phosphorus and blood iPTH levels were significantly decreased (P <0.05). In addition, the clearance rates of serum phosphorus and iPTH in HP + HD group were significantly higher than HDF group (P <0.05). Conclusion Both HDF and HP + HD can effectively remove blood phosphorus and iPTH, while HP + HD is more effective.