1985年,我院内科对800例患腰背痛,其中部分为外院疑有强直性脊柱炎(AS)的病人,进行了临床及HLA-B_(27)检查。根据纽约诊断标准,确诊为AS病者80例,其发病年龄多在12～30岁之间,男女之比例为6.3∶1;72例AS病人之HLA-B_(27)阳性,5例病人有家族史,提示本病与遗传因素有关。部分病人做到了早期诊断。我们认为,对患腰背痛的病人进行HLA-B_(27)检查,可提高医生对AS发病之警觉。 In 1985, our department of internal medicine for 800 patients suffering from low back pain, some of which were suspected of ankylosing spondylitis (AS) in patients, for clinical and HLA-B_ (27) examination. According to New York diagnostic criteria, 80 patients were diagnosed as AS patients, the age of onset was between 12 and 30 years old, the ratio of male to female was 6.3:1; 72 AS patients were HLA-B 27 positive, 5 patients had Family history, suggesting that the disease and genetic factors. Some patients did early diagnosis. In our opinion, HLA-B_ (27) test in patients with low back pain can improve doctors’ alertness to the onset of AS.