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目的 研究鲁米那的负荷量合并小剂量安定对儿童癫癎持续状态的疗效,探讨其安全剂量。方法选择癫癎持续状态患儿共46例,其中治疗组23例,首先安定0.3mg/kg静脉注射后,给予鲁米那负荷量20mg/kg在30min-1h内静脉滴注,12h后给予维持量5mg/kg,对照组23例,同样首先安定0.3mg/kg静脉注射后,将安定20mg/kg加入250ml生理盐水持续缓慢静脉滴注,将二组疗效进行对照。结果 治疗组惊厥控制时间较对照组短P<0.05,药物的负作用二组无统计学差异,P>0.05。结论 负荷量的鲁米那合并小剂量安定对儿童癫癎持续状态是安全有效的治疗方法。
Objective To study the efficacy of luminal combined with low-dose diazepam on the sustained status of children with epilepsy and to explore its safe dosage. Methods A total of 46 children with epileptic seizures were enrolled in this study. Twenty-three patients in the treatment group were treated with 0.3 mg / kg intravenous injection of intravenous injection of LUMARINE 20 mg / kg intravenously within 30 min-1 h and maintained after 12 h The amount of 5mg / kg, the control group of 23 patients, the same first stable 0.3mg / kg intravenous injection, the stability of 20mg / kg added 250ml saline continuous slow intravenous infusion, the two groups were compared efficacy. Results The control group had shorter convulsion control time than the control group (P <0.05). There was no significant difference in the negative effect between the two groups (P> 0.05). Conclusion The loading of luminal combined with low-dose diazepam is a safe and effective treatment for children with status epilepticus.