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目的：测定大鼠颅脑液压损伤后脑组织内Ｎａ＋－Ｋ＋－ＡＴＰ酶活性，探讨其在继发性脑损伤中的作用。方法：利用大鼠颅脑液压损伤模型，在致伤后６小时测定脑组织含水量、脑组织内Ｎａ＋－Ｋ＋－ＡＴＰ酶活性。结果：脑损伤６小时后，损伤侧脑组织内含水量明显增加（Ｐ＜０．０５），Ｎａ＋－Ｋ＋－ＡＴＰ酶活性明显下降（Ｐ＜０．０５）；而未损伤侧脑组织含水量和脑内Ｎａ＋－Ｋ＋－ＡＴＰ酶活性均无显著改变（Ｐ＞０．０５）。结论：脑损伤后脑组织内Ｎａ＋－Ｋ＋－ＡＴＰ酶活性下降是继发性脑损害发生和发展的重要因素之一。
OBJECTIVE: To determine the Na + -K + -ATPase activity in the brain tissue of rat after craniocervical fluid pressure injury and to explore its role in secondary brain injury. Methods: The rat model of hydrocephalus was used to measure the water content of brain tissue and the activity of Na + -K + -ATPase in brain tissue at 6 hours after injury. Results: Six hours after injury, the water content in injured side brain tissue increased significantly (P <0.05) and the activity of Na + -K + -ATPase decreased significantly (P <0.05) And brain Na + -K + -ATPase activity had no significant change (P> 0.05). Conclusion: The decrease of Na + -K + -ATPase activity in brain tissue after brain injury is one of the important factors in the occurrence and development of secondary brain damage.