论文部分内容阅读
Decreased expression of glucose transporter 2 (GLUT2) has been found to correlate with impaired secreting β-cell function in diabetes. Here, the aim was to study if the GLUT2 of pancreatic islets is a target structure for streptozotocin (STZ) in vitro. GLLT2 expression was determined by Western blot analysis, using lysates prepared from islets of C57BL / 6mice. A dose-dependent decrement of GLUT2 expression was found after incubation of islets with streptozotocin for 30 min. Compared with solvent-incubated islets, a subtoxic dose (4mM) of STZ resulted in a reduction of approximate 58% of GLUT2 expression and a toxic dose
Here, the aim was to study if the GLUT2 of pancreatic islets is a target structure for streptozotocin (STZ) in vitro. GLLT2 (GLUT2) has been found to correlate with impaired secreting β-cell function in diabetes. Expression was determined by Western blot analysis, using lysates prepared from islets of C57BL / 6 mice. A dose-dependent decrement of GLUT2 expression was found after incubation of islets with streptozotocin for 30 min. Compared with solvent-incubated islets, a subtoxic dose (4 mM ) of STZ resulted in a reduction of approximate 58% of GLUT2 expression and a toxic dose