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Ki-67是一种与细胞分裂增殖有关的核蛋白,在有丝分裂的G0和G1早期不表达,G1中期到晚期出现,S期和G2期逐渐增加,M期到最高值,随后快速降解。由于其表达量随细胞周期不同而发生改变,在细胞周期各阶段有动态变化,起一种计时分子的作用,因此被认为是评估人体肿瘤生长的一种重要工具[1]。在血液肿瘤中,有大量的原始和幼稚细胞在骨髓、淋巴结中增殖,Ki-67的检测已广泛应用于血液肿瘤的诊断,疗效监测和预后判断。本文就Ki-67在血液肿瘤中的应用及其研究进展作一综述。
Ki-67 is a nuclear protein associated with cell division and proliferation, which is not expressed in mitotic G0 and G1 early phase, G1 to mid-late stage, S phase and G2 phase gradually increase, M phase to the highest value, then rapidly degraded. Because its expression varies with the cell cycle, it changes dynamically in all stages of the cell cycle and acts as a timing molecule. Therefore, it is considered as an important tool to evaluate human tumor growth [1]. In hematological tumors, a large number of primitive and immature cells proliferate in bone marrow and lymph nodes. The detection of Ki-67 has been widely used in the diagnosis, curative effect and prognosis of hematological tumors. This article reviews the application of Ki-67 in hematological tumors and its research progress.