以金黄色葡萄球菌、蜡状芽胞杆菌、枯草芽胞杆菌、大肠杆菌、鼠伤沙门氏菌及肠炎沙门氏菌为测试菌种,对从西洋参(Panax quinquefolium L.)的茎和叶中分离得到的36株内生真菌进行抑菌活性试验,并测定活性菌株的代谢产物和不同极性物质对测试病菌的抑菌活性。试验筛选出2株具有明显抑菌活性的内生真菌,它们的代谢产物和不同极性物质对金黄色葡萄球菌和蜡状芽胞杆菌的抑菌效果最佳,其中胞外多糖和正丁醇提取物的抑菌效果较好。 Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Escherichia coli, Salmonella enteritidis and Salmonella enteritidis were used as tested bacterial strains. 36 endophytes isolated from stems and leaves of Panax quinquefolium L. Fungi antibacterial activity test and determination of active metabolites of the strains and different polar substances on the test bacteria antibacterial activity. Two strains of endophytic fungi with obvious bacteriostasis activity were screened out. Their metabolites and different polar substances had the best antibacterial effect on Staphylococcus aureus and Bacillus cereus. Among them, exopolysaccharides and n-butanol extracts The antibacterial effect is better.