This paper chooses the Spanish translation of the address to the China-CELAC Forum opening ceremony as a research corpus and adopts Skopos theory and its three basic rules as a theoretical guide to discuss the principles of Spanish translation of the conference address, the features of translation of words and sentences with Chinese characteristics, and the applicability of three rules of Skopos theory to Chinese-Spanish translation of international conference addresses. In Chinese-Spanish translation, the translator should convey the meaning of the source text while meeting the desired needs of the target audience under the guidance of Skopos theory to avert conflict between output content and reader ideology and fulfill cross-cultural communication.