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药物引致白细胞数增加可能具有增强细胞免疫的生理意义或药物毒性反应的病理意义。我省研制新药甲基小蘖胺对动物白细胞数的影响,文献有初步介绍,但未作定论,需要进一步试验研究为临床应用提供参考。现将我们试验结果报道如下: 方法甲基小蘖胺由贵阳制药厂提供样品,本药试用于人时刺激性较大,肌注局部疼痛较剧。为避免刺激性大干扰试验结果,注射剂中加入奴弗卡因、配成每100毫升溶液含甲基小蘖胺250毫克及奴弗卡因675毫克。试验动物为健康小自鼠,取尾血作白细胞计数。试验中采用自
An increase in the number of leukocytes induced by the drug may have the physiological significance of enhancing cellular immunity or the pathological significance of drug toxicity. The effect of the new drug methyl bromide on the leukocyte count in our province has been introduced in the literature. However, no conclusions have been made and further experimental studies are needed to provide reference for clinical application. Now we report the results of the test are as follows: Methods Mecaprolamine provided by the Guiyang Pharmaceutical Factory sample, the drug used in the test of human irritation, intramuscular local pain more drama. In order to avoid the result of irritating large interference test, nobucaine was added to the injection, and 250 mg of methyl berylamine and 675 mg of novocaine were added per 100 ml of the solution. The test animals were healthy small mice and tail blood was taken for white blood cell counts. Used in the test