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三叶因子家族是一群主要由胃肠道黏液细胞分泌的小分子多肽.其共同特征为均含一特殊的P结构域及三叶状结构.这种稳定的结构使三叶因子家族具有明显的抗蛋白酶水解、酸消化及耐热特性,因而能在消化道复杂的环境中保持生物活性.目前在哺乳动物体内发现的有pS2/TFF1、SP/TFF2和ITF/TFF3三种,它们具有黏膜保护与修复、肿瘤抑制、信号传导、调节细胞凋亡等功能.本文阐述了三叶因子家族发现的历史,并初步探讨了其作用.同时也对三叶因子受体这一热点的研究现状进行总结.
The trefoil factor family is a group of small molecule peptides that are mainly secreted by gastrointestinal mucus cells and share a common P domain and trilobal structure. This stable structure allows the trefoil factor family to have significant Anti-protease hydrolysis, acid digestion and heat-resistant properties, and thus be able to maintain biological activity in the complex environment of the digestive tract.Currently found in mammals have pS2 / TFF1, SP / TFF2 and ITF / TFF3 three, they have mucosal protection And repair, tumor suppression, signal transduction, regulation of apoptosis, etc. This article describes the history of the discovery of the trefoil factor family and its role in the preliminary study, and also summarizes the current research status of the trefoil factor receptor .