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目的:探讨奥美拉唑治疗新生儿应激性溃疡的临床疗效。方法:将56例患应激性溃疡的新生儿随机分为治疗组30例和对照组26例,在综合治疗基础上,治疗组静脉注射奥美拉唑0.5～0.8 mg/(kg.d),1次/d,对照组给予去甲肾上腺素0.4 mg+NS 10 mL胃管内注入,每6 h一次,比较两种方法治疗新生儿应激性溃疡的疗效。结果:治疗组总有效率80.0%,对照组总有效率42.3%,两组比较差异有统计学意义(P<0.01)。治疗组循环不良消失、胃肠功能紊乱消失、意识恢复、神经反射恢复及肌张力恢复时间均短于对照组,差异均有统计学意义(P<0.05)。结论:奥美拉唑治疗新生儿应激性溃疡疗效显著,未见明显不良反应发生。
Objective: To investigate the clinical efficacy of omeprazole in the treatment of neonatal stress ulcer. Methods: Fifty-six neonates with stress ulcer were randomly divided into treatment group (30 cases) and control group (26 cases). On the basis of comprehensive treatment, the treatment group received omeprazole 0.5-0.8 mg / (kg · d) , Once a day, the control group was given norepinephrine 0.4 mg + NS 10 mL intratracheal instillation, once every 6 h, to compare the efficacy of two methods to treat neonatal stress ulcer. Results: The total effective rate was 80.0% in the treatment group and 42.3% in the control group, with significant difference between the two groups (P <0.01). In the treatment group, the circulatory dysfunction disappeared, the gastrointestinal dysfunction disappeared, the consciousness recovery, the nerve reflex recovery and the muscle tone recovery time were all shorter than those in the control group. The difference was statistically significant (P <0.05). Conclusion: Omeprazole treatment of neonatal stress ulcer significant effect, no significant adverse reactions.